GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10540 | 1 | rs12418639 | chr11:473300 | RNH1 | chr11:494512-507273:- | 0.17 | 4.25 | 2.34E-5 | Body mass index |
| BRCA | cis | rs7927771 | 1 | rs12418852 | chr11:47868853 | MADD | chr11:47290927-47351582:+ | 0.14 | 4.44 | 9.81E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12418852 | chr11:47868853 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.14 | 3.74E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12419692 | chr11:47624714 | C1QTNF4 | chr11:47611216-47615961:- | 0.11 | 3.51 | 0.00047 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12419692 | chr11:47624714 | MADD | chr11:47290927-47351582:+ | -0.11 | -3.39 | 0.000729 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12419692 | chr11:47624714 | MYBPC3 | chr11:47352958-47374253:- | 0.13 | 3.79 | 0.000159 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12421210 | chr11:47779586 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.51 | 7.28E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12421210 | chr11:47779586 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.29 | 1.98E-5 | Subjective well-being |
| BRCA | cis | rs10444533 | 1 | rs12424054 | chr12:107186747 | C12orf23 | chr12:107349544-107367811:+ | 0.15 | 3.48 | 0.000531 | Social autistic-like traits |
| BRCA | cis | rs10444533 | 1 | rs12424054 | chr12:107186747 | MTERFD3 | chr12:107371069-107380929:- | 0.16 | 4.24 | 2.45E-5 | Social autistic-like traits |
| BRCA | cis | rs7957197 | 1 | rs12425790 | chr12:121452504 | HNF1A | chr12:121416549-121440312:+ | -0.19 | -3.57 | 0.000379 | Type 2 diabetes |
| BRCA | cis | rs7267979 | 1 | rs12428 | chr20:25433821 | FAM182A | chr20:26035250-26067552:+ | 0.22 | 5.74 | 1.21E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs12428 | chr20:25433821 | FAM182B | chr20:25744102-25848786:- | -0.24 | -6.26 | 5.41E-10 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs12435908 | 1 | rs12433827 | chr14:66055610 | LOC645431 | chr14:65877313-65879335:- | -0.27 | -5.39 | 8.62E-8 | Ischemic stroke |
| BRCA | cis | rs12435908 | 1 | rs12435908 | chr14:66121468 | LOC645431 | chr14:65877313-65879335:- | 0.21 | 4.51 | 7.18E-6 | Ischemic stroke |